ARCHER2 Calendar December 2024
By ARCHER2 Calendar on December 1, 2024
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Silico model for assessing individual responses to irregular heart rhythm treatments.
Carlos Edgar Lopez Barrera, Queen Mary University of London, SEMS
* * * Winning Early Career entry, ARCHER2 Image and Video Competition 2023 * * *
This video demonstrates the creation of a personalized in silico model for assessing individual responses to irregular heart rhythm treatments. These customized computational models can predict how a patient will react to therapy and facilitate virtual trials. The process starts with a point cloud extracted from a segmented MRI scan, providing a spatial representation of the atrium. These points are interconnected to form a 3D finite element mesh that reflects the patient's unique anatomy. The cardiac tissue's directional properties, influenced by atrial fiber orientation, are incorporated from a DT-MRI atlas. The model then simulates electrical activity and electrograms using the openCARP solver to explore irregular heart rhythms like atrial fibrillation. Post-simulation analysis identifies critical atrial fibrillation regions. Procedures like radiofrequency catheter ablation or anti-arrhythmic drug administration can be virtually tested to predict the patient's individualized response, as demonstrated in this case with pulmonary vein isolation ablation therapy.
This image was published on the December page of the ARCHER2 2024 printed calendar.